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<B>MCI, Neuropsychiatric Symptoms, and Functional Impairment 
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   Lead Investigator:    Angela Jefferson
   Institution      :    Vanderbilt (prev Boston University)
   E-Mail           :    angela.jefferson@Vanderbilt.Edu
   Proposal ID      :    123
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>Abstract:  This project aims to study the relationship between mild cognitive impairment subtypes, neuropsychiatric symptoms, and functional impairment.  A past distinction between individuals with MCI and individuals with dementia has been the lack of functional impairment in MCI. However, a 2003 consensus revision of the MCI diagnostic criteria modified the activities of daily living (ADLs) criterion from full preservation of ADLs to allow for minimal impairment in instrumental ADLs (IADLs).  It is also known that individuals with MCI are more  likely to report neuropsychiatric symptoms as compared to cognitively normal individuals. Previous studies have evaluated the differences in neuropsychiatric symptoms between MCI subtypes, but have found inconsistent results.  What is less well characterized is the relationship between these neuropsychiatric symptoms and functional ability between MCI subtypes. This study aims to cross-sectionally and longitudinally study the cognitive and functional change over time within MCI subtypes, with respect to neuropsychiatric symptoms. </textarea>